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Friday, July 17, 2020 | History

4 edition of The Ras superfamily of GTPases found in the catalog.

The Ras superfamily of GTPases

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  • 19 Currently reading

Published by CRC Press in Boca Raton .
Written in English

    Subjects:
  • Ras oncogenes.,
  • Guanosine triphosphatase.,
  • Guanosine triphosphatase genes.,
  • Ras proteins.,
  • GTPase-activating protein.,
  • Cell transformation.

  • Edition Notes

    Includes bibliographical references and index.

    Statement[edited by] Juan Carlos Lacal, Frank McCormick.
    ContributionsLacal, Juan Carlos., McCormick, Frank, 1950-
    Classifications
    LC ClassificationsRC268.44.R37 R38 1993
    The Physical Object
    Pagination526 p., [3] p. of plates :
    Number of Pages526
    ID Numbers
    Open LibraryOL1739587M
    ISBN 100849352142
    LC Control Number92044952

    This review summarizes current fluorescence-based techniques for studying Ras superfamily GTPases with an emphasis on practical examples and high-throughput applications. These techniques are not only useful for biochemical characterization of Ras superfamily members, but will also facilitate the discovery of small molecule therapeutics. If the key aspects of these RAS superfamily pathways can be understood and targeted [11–14], this may lead to better strategies to modulate these critical pathways. The recent findings with RAS-related genes in human genetics emphasize several salient points. First, conserved RAS-related genes may have important genotype–phenotype : Joseph T. C. Shieh.

    Keywords:Cancer, Fragment-based drug design, GTPase, Structure-based drug design, Rab, Ras, X-ray crystallography. Abstract:The Ras superfamily of small monomeric GTPases includes some of the most prominent cancer targets for which no selective therapeutic agent has yet been successfully developed. The turn of the millennium saw a resurgence of Cited by: 7.   Identification and Classification of Small GTPase Genes in Arabidopsis. To identify small GTPase genes in the Arabidopsis genome, we first compiled sequences previously documented in S. cerevisiaeand humans as members of the small GTP-binding protein superfamily of regulatory genes were classified into the five accepted families of small GTPases .

    About this book Using a multidisciplinary approach, it features contributions and discussions of the latest research from leading scientists working on all aspects of GTPase activity. Covers all known members of the important superfamily of enzymes--the GTPases. The Ras superfamily. There are more than a hundred proteins in the Ras superfamily. Based on structure, sequence and function, the Ras superfamily is divided into five main families, (Ras, Rho, Ran, Rab and Arf GTPases). The Ras family itself is further divided into 6 subfamilies: Ras, Ral, Rit, Rap, Rheb, and : BRENDA entry.


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The Ras superfamily of GTPases Download PDF EPUB FB2

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related : Juan Carlos Lacal.

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases. The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related : Juan Carlos Lacal, Frank Patrick McCormick.

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases.

The book's chapters were written by the world's most prominent scientists in this field and cover such topics as the structure and properties of ras proteins, ras function, the ras superfamily in general, and the functional regulation of ras and ras-related cturer: CRC Press.

The ras Superfamily of GTPases () book. The ras Superfamily of GTPases () DOI link for The ras Superfamily of GTPases () The ras Superfamily of GTPases () book. By Juan Carlos Lacal, Frank Patrick McCormick. Edition 1st Edition. First Published eBook Published 22 November Medical Science Nonfiction The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases.

SinceRas proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators ofBrand: Springer Netherlands.

In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the s the pro- oncogene Ras itself was the focus of interest, though in the s this shifted to the increasing variety of Ras.

Part of the Methods in Molecular Biology book series (MIMB, volume ) The Ras superfamily of small GTPases is composed of more than members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on by binding GTP and off by hydrolyzing GTP to by: The Ras superfamily of small GTPases comprises a group of molecular switches that regulate an astonishing diversity of cellular functions.

A deep understanding of mitogenesis, cytoskeletal. Publisher Summary The Rho family of GTPases is a family of small signaling G protein, and is a subfamily of the Ras superfamily.

The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found in all eukaryotic organisms including yeasts and some plants. Third, Ras proteins are founding members of a large superfamily of Ras-related small.

GTPases. Over Ras-related small GTPases are found in the human genome, with. orthologs found in all vertebrate species and invertebrates. This book features chapters by leading investigators in the field that highlight the.

Based on variations in structure, post-translational modifications and interactions with effector and regulator proteins, the Ras superfamily GTPases function as sophisticated modulators of a complex and diverse range of cellular processes [2] and play critical roles in various biological processes [3–5].

Based on sequence and similarity, the Ras superfamily can be divided into. Ras superfamily GTPase biochemistry and regulation Small GTPases exhibit high-affinity binding for GDP and GTP, and possess low intrinsic GTP hydrolysis and GDP/GTP exchange activities.

GDP/GTP cycling is controlled by two main classes of regulatory by:   Small GTPases of the Ras superfamily are key regulators of diverse cellular and developmental events, including differentiation, cell division, vesicle transport, nuclear assembly, and control of the cytoskeleton. The C.

elegans genome encodes 56 members of the major Ras GTPase subfamilies, including the Ras/Ral/Rap family, Author: Erik A.

Lundquist. The Ras superfamily is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ras, Rho, Ran, Rab and Arf GTPases.

The Ras family itself is further divided into 6 subfamilies: Ras, Ral, Rap, Rheb, Rad and Rit. Miro is a recent contributor to the InterPro: IPR Description: This book contains a series of protocols for working with RAS GTPases. The major groups in the RAS superfamily are represented.

Purpose: The aim is to provide a set of standardized protocols for working with this group of proteins. This is a suitable objective and largely : $ The Ras superfamily of small GTPases is composed of more than members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on.

The Ras homologous (Rho) protein family is a member of the Ras superfamily of small GTPases. Small GTPases are monomeric proteins and function as molecular switches that turn “on” or turn “off” signal transduction pathways in response to chemical or mechanical stimuli.

The Ras superfamily of small GTPases comprises a group of molecular switches that regulate an astonishing diversity of cellular functions. A deep understanding of mitogenesis, cytoskeletal organization, vesicle traffic, and nuclear transport now requires the inclusion of the small GTPases as essential components of the molecular machines that drive these by: "The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-related GTPases.

GTPase Protocols. The Ras Superfamily | Ed Manser, Thomas Leung | download | B–OK. Download books for free. Find books. The RAS superfamily of GTP (guanosine triphosphate) hydrolysis-coupled signal transduction relay proteins can be subclassified into RAS, RHO, RAB, and ARF families, as well as the closely related Galpha by: Ras-superfamily GTPases in C.

elegans. Small GTPases of the Ras superfamily are key regulators of diverse cellular and developmental events, including differentiation, cell division, vesicle transport, nuclear assembly, and control of the cytoskeleton.